| ORA | CASA | OSPITI | BET | RE | FIN | MARCATORE | QT 1°M |
| 19:30 | FC Porto | Guimaraes | 1 | 3:0 | 3:0 | Moussa Marega | 4 |
| 21:00 | Marsiglia | St. Etienne | 1 | 1:0 | 1:0 | Dario Benedetto | 6 |
| 12:00 | Aarhus | Esbjerg | 1 | 1:0 | 1:0 | Nicklas Helenius | 6 |
| 15:00 | Ternana | Potenza | 1 | 1:0 | 1:0 | ||
| 15:00 | Sundsvall | Göteborg | 2 | 0:2 | 0:2 | ||
| 17:00 | Valencia | Maiorca | 1 | 2:0 | 2:0 | Kevin Gameiro | 5,5 |
| 17:30 | Monza | Novara | 1 | 2:0 | 2:0 | ||
| 18:15 | Genclerbirligi | Basaksehir | X2 | 1:2 | 1:2 | ||
| 20:45 | Genoa | Fiorentina | 1X | 2:1 | 2:1 | Lasse Schone | 11 |
| 20:45 | Yeni Malatyaspor | Alanyaspor | X2 | 2:3 | 2:3 | ||
| 01:00 | Huila | Tolima | X2 | 0:1 | 0:1 | ||
| 03:00 | Atl. Nacional | Millonarios | X | 1:1 | 1:1 | ||
| 13:30 | Osnabruck | Karlsruher | 1X | 1:1 | 3:0 | Marcos Alvarez | 7,5 |
| 17:30 | Hacken | Falkenbergs | 1 | 2:0 | 4:1 | Paulinho | 5 |
| 20:45 | Cagliari | Inter | 2 | 0:2 | 1:2 | Lautaro Martinez | 5 |
| 20:45 | Sassuolo | Sampdoria | 1X+GOAL | 2:1 | 4:1 | Domenico Berardi | 6,5 |
| 21:00 | Flamengo | Palmeiras | 1 | 2:0 | 3:0 | Gabriel Barbosa | 5 |
| 21:00 | Villarreal | Real Madrid | 1X+GOAL | 3:2 | 2:2 | Gerard Moreno | ? |
| 12:15 | Twente | Utrecht | X2 | 1:1 | 3:1 | Aitor Cantalapiedra | 11 |
| 14:00 | Horsens | Lyngby | X2 | 1:1 | 2:1 | Frederik Gytkjaer | 7 |
| 18:00 | Francoforte | Dusseldorf | 2 | 1:2 | 2:1 | Rouwen Hennings | 11 |
| 14:30 | Sparta Rotterdam | Ajax | 2 | 0:2 | 1:4 | Hakim Ziyech | 5,5 |
| 17:30 | Arsenal | Tottenham | 1X+GOAL | 3:2 | 2:2 | Aubameyang | 5,5 |
| 18:00 | PAOK | Panionios | 1 | 3:0 | 2:1 | Karol Swiderski | 4,33 |
| 19:00 | Atl. Madrid | Eibar | 1 | 2:0 | 3:2 | Victor Vitolo | 12 |
| 00:30 | Seattle Sounders | Los Angeles Galaxy | X2+GOAL | 2:3 | 4:3 | Zlatan Ibrahimovic | 4,75 |
| 13:00 | Ural | Krasnodar | 2 | 0:1 | 2:4 | Marcus Berg | 5,5 |
| 13:30 | Amburgo | Hannover | 1X+O1,5 | 2:1 | 3:0 | Lukas Hinterseer | 4,33 |
| 13:30 | Kiel | Aue | X2+GOAL | 1:2 | 1:1 | Pascal Testroet | 7,5 |
| 14:00 | Randers | Silkeborg | 1 | 2:1 | 2:0 | Marvin Egho | 6,5 |
| 15:00 | Juventus U23 | Siena | X2 | 1:2 | 2:3 | ||
| 15:00 | Olbia | Giana Erminio | 1 | 2:0 | 2:1 | ||
| 15:00 | Padova | AJ Fano | 1 | 2:0 | 6:1 | ||
| 15:00 | Südtirol | Carpi | X2 | 1:2 | 2:3 | ||
| 15:00 | Picerno | Rieti | 1X+U3,5 | 0:0 | 2:1 | ||
| 15:00 | Brommapojkarna | Syrianska | X2 | 2:3 | 1:1 | ||
| 15:00 | Jonkopings | Orgryte | 1 | 1:0 | 5:2 | ||
| 15:30 | Brema | Augusta | 1X+GOAL | 3:3 | 3:2 | Niclas Fullkrug | 6,5 |
| 15:30 | Arsenal Tula | CSKA Mosca | X2+U3,5 | 0:1 | 1:2 | Fedor Chalov | 4,75 |
| 16:00 | Colon | Rosario | X | 0:0 | 1:1 | ||
| 16:00 | Olimpik Donetsk | Shakhtar | 2+O2,5 | 0:3 | 0:4 | ||
| 16:45 | Vitesse | Alkmaar | 1X | 2:2 | 2:1 | Brian Linssen | 6,5 |
| 17:00 | Strasburgo | Monaco | X2 | 0:1 | 2:2 | Ben Yedder | 6 |
| 17:00 | Tondela | Santa Clara | X2 | 1:1 | 0:0 | Guilherme Schettine | 8 |
| 17:30 | Imolese | ArzignanoChiampo | X2 | 1:1 | 0:0 | ||
| 17:30 | L.R. Vicenza | Fermana | 1 | 1:0 | 3:1 | ||
| 17:30 | Ravenna | Reggio Audace | X2 | 0:0 | 1:2 | ||
| 17:30 | Sambenedettese | Triestina | X2 | 1:2 | 0:0 | ||
| 17:30 | Casertana | Rende | 1 | 1:0 | 2:0 | ||
| 17:30 | Catania | Virtus Francavilla | 1 | 3:0 | 2:1 | ||
| 17:30 | Reggina 1914 | Cavese | 1 | 2:1 | 5:1 | ||
| 17:30 | Dalkurd | Norrby | 1 | 1:0 | 3:1 | ||
| 18:00 | Lazio | Roma | 1X | 2:1 | 1:1 | Joaquin Correa | 9 |
| 18:00 | Juve Stabia | Pisa | X2 | 1:1 | 0:2 | Karamoko Cisse | 6,5 |
| 18:00 | Sarpsborg 08 | Viking | X | 1:1 | 2:2 | Zachariassen | 9,5 |
| 18:00 | Tromsø | Haugesund | 1X | 2:1 | 2:2 | Onni Valakari | 11 |
| 18:00 | Gijon | Albacete | 1DNB | 1:0 | 2:0 | ||
| 18:00 | Vallecano | La Coruna | 1X | 2:1 | 3:1 | ||
| 18:15 | Newells Old Boys | Huracan | 1 | 1:0 | 4:1 | ||
| 18:15 | Talleres Cordoba | Aldosivi | 1 | 2:0 | 2:1 | ||
| 18:15 | AEL Larissa | Olympiakos | 2 | 0:2 | 0:1 | ||
| 18:30 | Zorya | Dyn. Kyiv | X+GOAL | 1:1 | 2:2 | ||
| 19:00 | Lamia | Atromitos | X | 0:0 | 2:2 | ||
| 19:00 | Espanyol | Granada | X2 | 1:1 | 0:3 | Fede Vico | 11 |
| 19:30 | Estudiantes Rio Cuarto | Ind. Rivadavia | 1 | 2:0 | 3:1 | ||
| 20:00 | Gent | Cercle Brugge | 1 | 3:0 | 3:2 | ||
| 20:00 | Vålerenga | Rosenborg | X2 | 1:2 | 1:1 | Soderlund | 6,5 |
| 20:00 | Waalwijk | PSV | 2+O2,5 | 0:3 | 1:3 | Donyell Malen | 4,33 |
| 20:15 | Molinos El Pirata | Carlos Mannucci | X2 | 1:1 | 0:0 | ||
| 20:45 | Fenerbahce | Trabzonspor | X2+GOAL | 2:2 | 1:1 | ||
| 21:00 | Cadice | Extremadura UD | 1 | 1:0 | 2:1 | ||
| 22:00 | River Plate | Boca Juniors | 1X | 2:2 | 0:0 | Rafael Borre | ? |
| 22:00 | Braga | Benfica | 2 | 1:2 | 0:4 | Haris Seferovic | 5 |
| 23:00 | Dep. Cali | Pasto | 1 | 1:0 | 3:1 | ||
| 23:00 | Dep. Municipal | A. Lima | 1X | 2:1 | 2:2 | ||
| 00:00 | Santa Fe | Ind. Medellin | 1X | 0:0 | 2:0 | ||
| 00:30 | Guarani | Diaz | 1 | 2:1 | 5:0 | ||
| 01:00 | Bucaramanga | Junior | 1X | 1:0 | 0:0 | ||
| 01:30 | CA Mitre | San Martin S.J. | X2 | 1:1 | 0:1 |
