| ORA | CASA | OSPITI | BET | RE | FIN | MARCATORE | QT 1°M |
| 10:30 | Ufa | Orenburg | 1 | 1:0 | 1:2 | Daniil Fomin | 8,5 |
| 13:00 | Bielefeld | Furth | X2 | 1:1 | 2:2 | Julian Green | 12 |
| 13:00 | Dresda | St. Pauli | X2 | 0:1 | 3:3 | D. Diamantakos | 7 |
| 13:00 | Wehen | Regensburg | X2 | 2:2 | 0:5 | Nielsen Albers | 7,5 |
| 13:00 | Kazan | Sochi | 1 | 1:0 | 0:3 | Evgeni Markov | 7 |
| 13:30 | Southampton | Manchester Utd | X2+U3,5 | 1:1 | 1:1 | Paul Pogba | 7,5 |
| 13:30 | Bristol City | Middlesbrough | 1 | 2:1 | 2:2 | Andreas Weimann | 7 |
| 13:30 | Elfsborg | Sirius | 1 | 2:1 | 1:1 | Jesper Karlsson | 6,5 |
| 13:30 | Degerfors | Halmstad | X2 | 2:2 | 2:1 | ||
| 14:00 | KPV | Honka | 1X | 2:1 | 0:1 | ||
| 15:00 | SJK | KuPS | 2 | 0:2 | 1:3 | ||
| 15:00 | Lorient | Guingamp | 1 | 1:0 | 0:1 | ||
| 15:30 | Bayern | Magonza | 1+O2,5 | 4:0 | 6:1 | Serge Gnabry | 5,5 |
| 15:30 | Friburgo | Colonia | 1X+O1,5 | 2:1 | 1:2 | Luca Waldschmidt | 6,5 |
| 15:30 | Leverkusen | Hoffenheim | 1X+GOAL | 3:2 | 0:0 | Kai Havertz | 5,5 |
| 15:30 | Schalke | Hertha | X2 | 1:2 | 2:0 | Dodi Lukebakio | 8 |
| 15:30 | Wolfsburg | Paderborn | X2+GOAL | 3:3 | 1:1 | Sven Michel | 11 |
| 15:30 | Lok. Mosca | FK Rostov | 1 | 2:1 | 1:2 | Fedor Smolov | 4,5 |
| 16:00 | Sao Paulo | Gremio | 1 | 2:1 | 0:0 | Dani Alves | 9,5 |
| 16:00 | Oeste | Sport Recife | X2 | 1:1 | 0:0 | ||
| 16:00 | Nordsjaelland | Hobro | X | 2:2 | 2:1 | Godsway Donyoh | 5 |
| 16:00 | Ilves | Inter Turku | X | 1:1 | 0:1 | ||
| 16:00 | VPS | HIFK | 1X | 1:1 | 3:2 | ||
| 16:00 | Chelsea | Sheffield Utd | 1 | 2:1 | 2:2 | Christian Pulisic | 7 |
| 16:00 | Crystal Palace | Aston Villa | 2DNB | 1:2 | 1:0 | Wesley | 7,5 |
| 16:00 | Leicester | Bournemouth | X | 1:1 | 3:1 | Joshua King | 9,5 |
| 16:00 | Manchester City | Brighton | 1+O2,5 | 3:0 | 4:0 | Raheem Sterling | 4,33 |
| 16:00 | Newcastle | Watford | X2 | 0:1 | 1:1 | Andre Gray | 7 |
| 16:00 | West Ham | Norwich | 1X+GOAL | 3:2 | 2:0 | Sebastien Haller | 5 |
| 16:00 | Birmingham | Stoke | 1X | 1:0 | 2:1 | Lukas Jutkiewicz | 7 |
| 16:00 | Brentford | Derby | X2 | 1:1 | 3:0 | Martyn Waghorn | 6,5 |
| 16:00 | Leeds | Swansea | X2 | 2:2 | 0:1 | Borja Baston | 7,5 |
| 16:00 | Luton | Huddersfield | 1X+O1,5 | 1:1 | 2:1 | James Collins | 6 |
| 16:00 | Millwall | Hull | X | 1:1 | 1:1 | Jarrod Bowen | 7,5 |
| 16:00 | Nottingham | Preston | 1DNB | 1:0 | 1:1 | Lewis Grabban | 5,5 |
| 16:00 | Reading | Charlton | X2+GOAL | 2:3 | 0:2 | Lyle Taylor | 5,5 |
| 16:00 | Sheffield Wed | QPR | 1 | 2:1 | 1:2 | Fernando Forestieri | 6 |
| 16:00 | West Brom | Blackburn | X | 0:0 | 3:2 | ||
| 16:00 | Wigan | Barnsley | 1DNB | 1:0 | 0:0 | Michael Jacobs | 10 |
| 16:00 | Accrington | Milton Keynes | X2 | 0:1 | 2:1 | ||
| 16:00 | Blackpool | Portsmouth | X | 0:0 | 1:1 | ||
| 16:00 | Burton | Bristol Rovers | 1 | 1:0 | 2:0 | ||
| 16:00 | Gillingham FC | Bolton | X | 1:1 | 5:0 | ||
| 16:00 | Ipswich | Shrewsbury | 1 | 2:0 | 3:0 | ||
| 16:00 | Lincoln | Fleetwood | X | 2:2 | 2:0 | ||
| 16:00 | Oxford Utd | Coventry | X2 | 1:2 | 3:3 | ||
| 16:00 | Peterborough | Sunderland | 2 | 1:3 | 3:0 | ||
| 16:00 | Rotherham | Tranmere | X2 | 1:1 | 1:1 | ||
| 16:00 | Southend | Rochdale | 2 | 1:2 | 0:3 | ||
| 16:00 | Wimbledon | Wycombe | 2 | 1:3 | 0:0 | ||
| 16:00 | Crawley | Cheltenham | 1 | 2:1 | 1:0 | ||
| 16:00 | Crewe | Bradford City | X2 | 0:1 | 2:1 | ||
| 16:00 | Exeter | Mansfield | 1 | 2:0 | 1:0 | ||
| 16:00 | Forest Green | Newport | 1X | 0:0 | 0:2 | ||
| 16:00 | Northampton | Plymouth | 2 | 0:2 | 3:1 | ||
| 16:00 | Oldham | Colchester | X | 1:1 | 0:1 | ||
| 16:00 | Port Vale | Cambridge Utd | X2 | 1:1 | 1:0 | ||
| 16:00 | Salford | Leyton Orient | 1X | 2:1 | 1:1 | ||
| 16:00 | Scunthorpe | Carlisle | X2 | 1:2 | 0:1 | ||
| 16:00 | Stevenage | Macclesfield | X | 0:0 | 2:2 | ||
| 16:00 | Swindon | Morecambe | 1 | 3:1 | 3:1 | ||
| 16:00 | Walsall | Grimsby | X2 | 0:1 | 1:3 | ||
| 16:00 | Aberdeen | Ross County | 1 | 2:0 | 3:0 | Sam Cosgrove | 4,75 |
| 16:00 | Hearts | Hamilton | 1 | 1:0 | 2:2 | Conor Washington | 5 |
| 16:00 | Livingston | St. Mirren | X | 1:1 | 2:1 | Lyndon Dykes | 8,5 |
| 16:00 | Motherwell | Hibernian | 1X | 2:1 | 3:0 | Christopher Long | 7,5 |
| 16:00 | St. Johnstone | Kilmarnock | 1X | 1:1 | 0:1 | Callum Hendry | 7,5 |
| 16:00 | Örebro | AFC Eskilstuna | 1 | 2:1 | 3:1 | Jake Larsson | 6,5 |
| 16:00 | Mjallby | IK Frej | 1 | 3:1 | 2:1 | ||
| 16:00 | Dnipro-1 | Kolos Kovalivka | X2 | 0:1 | 2:1 | ||
| 16:00 | Vorskla | Oleksandriya | 1X | 2:1 | 0:1 | ||
| 16:35 | Chacarita Juniors | Santamarina | X | 0:0 | 0:3 | ||
| 17:00 | Pianese | Arezzo | 2 | 0:2 | 1:0 | ||
| 17:00 | Osasuna | Barcellona | 2 | 0:2 | 2:2 | Carles Perez Sayol | 6 |
| 17:30 | Lione | Bordeaux | 1 | 2:0 | 1:1 | Moussa Dembele | 4 |
| 17:30 | Paganese | Monopoli | 2 | 0:1 | 2:0 | ||
| 17:30 | Aves | Famalicao | X2 | 2:2 | 2:3 | Anderson | 8,5 |
| 17:30 | Ferreira | Maritimo | 1X | 2:1 | 0:1 | Douglas Tanque | 6 |
| 18:00 | Eupen | St. Truiden | 1X | 1:0 | 0:2 | ||
| 18:00 | Panetolikos | Xanthi | 1X | 1:0 | 1:2 | ||
| 18:00 | Milan | Brescia | 1 | 2:1 | 1:0 | Lucas Paqueta | 10 |
| 18:00 | Benevento | Cittadella | 1 | 2:0 | 4:1 | Roberto Insigne | 7,5 |
| 18:00 | Spezia | Crotone | 1 | 2:1 | 1:2 | Federico Ricci | 8,5 |
| 18:00 | Stabaek | Strömsgodset | 1 | 2:1 | 2:1 | Kasper Junker | 7 |
| 18:00 | U. San Martin | Union Comercio | X | 1:1 | 1:2 | ||
| 18:00 | Akhmat Grozny | Tambov | 1 | 1:0 | 1:1 | Ablay Mbengue | 6,5 |
| 18:00 | Fuenlabrada | R. Oviedo | 1X | 1:0 | 2:1 | ||
| 18:00 | Numancia | Mirandes | X | 0:0 | 2:0 | ||
| 18:00 | Varbergs | Östers | 1 | 1:0 | 0:0 | ||
| 18:05 | Tigre | All Boys | 1 | 1:0 | 2:0 | ||
| 18:15 | Argentinos Jrs | Gimnasia L.P. | 1 | 2:0 | 1:0 | ||
| 18:15 | Panathinaikos | OFI Crete | 1 | 2:0 | 1:3 | ||
| 18:15 | Konyaspor | Antalyaspor | X | 0:0 | 2:2 | ||
| 18:30 | Union Berlino | Dortmund | 2 | 0:3 | 3:1 | Jadon Sancho | 6 |
| 18:30 | Burnley | Liverpool | 2+GOAL | 1:2 | 0:3 | Mohamed Salah | 4 |
| 18:30 | Heerenveen | Sittard | 1 | 2:1 | 1:1 | Chidera Ejuke | 5 |
| 18:30 | Lviv | Mariupol | X2 | 1:2 | 0:1 | ||
| 19:00 | Getafe | Alaves | 1 | 1:0 | 1:1 | Jaime Mata | 5 |
| 19:00 | Levante | Valladolid | X | 1:1 | 2:0 | Marti Roger | 5 |
| 19:45 | Groningen | Heracles | 1 | 1:0 | 1:2 | Ajdin Hrustic | 11 |
| 20:00 | Kortrijk | Oostende | X2+GOAL | 2:2 | 2:2 | ||
| 20:00 | Angers | Dijon | 1 | 2:0 | 2:0 | Mathias Pereira | 9 |
| 20:00 | Nantes | Montpellier | 2 | 1:2 | 1:0 | Gaetan Laborde | 8 |
| 20:00 | Nimes | Brest | X | 0:0 | 3:0 | ||
| 20:00 | Tolosa | Amiens | 1X | 1:0 | 2:0 | Wesley Said | 7,5 |
| 20:00 | Sporting | Rio Ave | 1X+GOAL | 3:2 | 2:3 | Raphinha | 6,5 |
| 20:00 | Almeria | Huesca | 1X | 1:0 | 1:0 | ||
| 20:30 | San Lorenzo | Union Santa Fe | 1 | 2:0 | 2:1 | ||
| 20:30 | Brown Adrogue | Gimnasia Jujuy | 1DNB | 1:0 | 0:1 | ||
| 20:30 | Def. de Belgrano | Atl. Rafaela | X | 0:0 | 2:2 | ||
| 20:30 | Sarmiento Junin | San Martin Tucuman | 1 | 1:0 | 3:1 | ||
| 20:30 | Waasland-Beveren | Charleroi | 2 | 1:2 | 0:4 | ||
| 20:30 | Volos NFC | Aris | 1X | 1:1 | 1:0 | ||
| 20:45 | Juventus | Napoli | X2+GOAL | 1:2 | 4:3 | Dries Mertens | 8,5 |
| 20:45 | Piacenza | Modena | 1X+U3,5 | 1:1 | 2:1 | ||
| 20:45 | Den Haag | Venlo | X2 | 1:1 | 1:0 | Tomas Necid | 5,5 |
| 20:45 | Besiktas | Rizespor | 1 | 2:0 | 1:1 | Adem Ljajic | ? |
| 20:45 | Goztepe | Denizlispor | X2 | 1:2 | 0:0 | Modou Barrow | ? |
| 21:00 | La Equidad | Petrolera | X2 | 0:1 | 1:2 | ||
| 21:00 | Cosenza | Salernitana | X2 | 1:1 | 0:1 | ||
| 21:00 | Cremonese | Entella | 1 | 2:0 | 0:1 | Simone Palombi | 6 |
| 21:00 | Livorno | Perugia | X2 | 1:1 | 0:1 | Pietro Iemmello | 7 |
| 21:00 | Trapani | Venezia | 1DNB | 2:1 | 0:1 | Felice Evacuo | 6,5 |
| 21:00 | Betis | Leganes | X | 1:1 | 2:1 | Nabil Fekir | 5,5 |
| 21:00 | Las Palmas | Santander | X | 0:0 | 2:2 | ||
| 21:30 | Bolivar | The Strongest | GOAL | 2:2 | 1:1 | ||
| 21:30 | Atletico GO | Sao Bento | 1 | 2:1 | 1:0 | ||
| 21:30 | Figueirense | Guarani | X2 | 1:2 | 0:1 | ||
| 21:30 | Londrina | CRB | X2 | 0:1 | 0:1 | ||
| 21:30 | Ponte Preta | Coritiba | X | 1:1 | 1:0 | ||
| 22:00 | Bahia | CSA | 1 | 1:0 | 1:0 | Gilberto | 4 |
| 22:30 | Cajamarca | Binacional | X2 | 0:1 | 0:0 | ||
| 22:30 | Gil Vicente | Setubal | 1 | 1:0 | 0:0 | Sandro Lima | 6 |
| 22:45 | Patronato | Independiente | 2 | 0:2 | 1:0 | ||
| 23:00 | U. Magdalena | Cucuta | 1X | 1:0 | 1:2 | ||
| 23:30 | J. Wilstermann | Nacional Potosi | 1 | 2:1 | 1:1 | ||
| 00:00 | Athletico-PR | Ceara | 1 | 1:0 | 1:0 | Marcelo | 7,5 |
| 00:00 | Chapecoense-SC | Santos | 1X | 1:1 | 0:1 | Everaldo | |
| 00:00 | America MG | Operario | 1 | 1:0 | 0:0 | ||
| 00:00 | Bragantino | Brasil de Pelotas | X | 1:1 | 2:1 | ||
| 00:00 | Once Caldas | America De Cali | 1X | 1:1 | 2:1 | ||
| 00:00 | Deportivo Santani | Nacional Asuncion | X2 | 0:1 | 3:1 | ||
| 00:45 | AD Cantolao | Sport Boys | 1X | 1:1 | 1:2 | ||
| 01:00 | Racing Club | Godoy Cruz | 1 | 2:0 | 3:1 | ||
| 01:00 | Jaguares de Cordoba | Patriotas | X2 | 1:1 | 1:1 | ||
| 01:00 | New York Red Bulls | Colorado Rapids | 1 | 3:1 | 0:2 | Daniel Royer | 5 |
| 01:30 | Columbus Crew | Chicago Fire | 1X | 1:1 | 1:1 | Gyasi Zardes | 4,75 |
| 01:30 | Montreal Impact | DC United | 1 | 2:1 | 0:3 | Maximiliano Urruti | 6,5 |
| 01:30 | New England Revolution | Toronto FC | 1X+GOAL | 2:2 | 1:1 | Carles Gil | 6,5 |
| 01:30 | Philadelphia Union | Atlanta United | X2 | 2:2 | 3:1 | Josef Martinez | 4,33 |
| 02:00 | Oriente Petrolero | Sport Boys | 1X | 2:1 | 3:2 | ||
| 02:00 | Internacional | Botafogo RJ | 1X+U2,5 | 1:1 | 3:2 | Autogoal | |
| 02:00 | FC Dallas | Cincinnati | 1 | 2:0 | 3:1 | Jesus Ferreira | 5 |
| 02:30 | Sporting Kansas City | Houston Dynamo | 1 | 2:1 | 1:0 | Johnny Russell | 5,5 |
| 03:00 | Envigado | Aguilas | X2 | 0:1 | 3:3 | ||
| 03:00 | U. de Deportes | Melgar | X2 | 1:2 | 2:1 | ||
| 04:00 | Vancouver Whitecaps | New York City | 2 | 0:1 | 1:3 | Heber | 4,5 |
| 04:30 | Portland Timbers | Real Salt Lake | 1X+GOAL | 1:1 | 1:0 | Albert Rusnak | 8,5 |
| 04:30 | San Jose Earthquakes | Orlando City | X2 | 1:1 | 3:0 | Nani |
